![]() AD also causes dehydroepiandrosterone deficiency causing additional symptoms seen only in women (loss of axillary/pubic hair, absence of pubarch in children, reduced libido and dry skin). Vitiligo and alopecia areata are often present. Symptoms of postural hypotension and hypoglycemia are late manifestations. Pigmentation of skin and mucous membranes (darkening of the skin especially in the palmar creases, knuckles, scars, oral mucosa and sites of friction) is a cardinal sign of AD. Common manifestations include fatigue, loss of energy, malaise, weight loss, nausea, anorexia (failure to thrive in children), muscle and joint pain. It presents insidiously with nonspecific symptoms that can be mistaken for other more prevalent conditions. ![]() Clinical descriptionÄisease onset peaks around 40 but it can occur at any age. ![]() The prevalence of AD is 1/9,000-1/6,900 in the developed countries.
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